I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). FSH 7.7 ( done 1 year ago ) First round , on bcp for 2.5 weeks. As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). Please whitelist our site to get all the best deals and offers from our partners. Trying concieve since 40 Estrogen/androgen priming protocol improves egg quality and . I will have retrieval hopefully this weekend and will let you know what happens. | Contributor. Fingers crossed that your period waits for the right day. I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. Many REs swear by this for DOR. (This was to work with their schedule, because they are closed on the weekends.) As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. unfortunately, it was just an age issue, which i knew all along, but i had to try. In my opinion, it's good to be at a place that uses it a lot. You currently have javascript disabled. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! [lcurtis8] For my first IVF they had me on Lupron. They are generally used for suppression in Long Lupron Protocols. This will be my first IVF round and I w, Hi All, Sign up now for your monthly dose of fertility info, experiences, and insight. The protocol can also be preceded by the use of BCPs even if you have DOR. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? You can see my sig. Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. In some cases, priming may not be required. Please re-enable javascript to access full functionality. I think you should ask your doctor though to make sure.Again, here is what happened to my protocolCycle day 1 - PeriodCycle day 24 (7 days post ovulation) - Start Estrace Cycle day 1 - Period Cycle day 2 - Last Estrace pill Cycle day 3 Blood work & ultrasound; antral follicle count. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? Looking for info/success stories with Estrogen priming protocol with DOR. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. Can you try to conceive the cycle that you estrogen prime? After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. Any info welcomed!! Weill Cornell Medical Center, Division Chief My clinic doesn't like it. 13 days stim. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. But I also realize I'm not a dr and should probably listen to their advice! The results are below and as you can see, success rates do seem to drop off after 300 IUs per day of gonadotropin. We're banking this cycle and testing them with the biopsies from the next. Best of luck to you. I was long Lupron and that one was cancelled because my precious RE only saw very few follies. That could be why they are decreasing your Follistim too. We ended up refinancing our home and getting help from family. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. I also did ganirelix during this time. Please enable JavaScript in your browser to load the challenge. Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. Please specify a reason for deleting this reply from the community. . To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). That could be bogus, but it makes sense, right? As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. This is called multi-follicular development and its a pivotal step in a successful IVF. It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. This amounts typically to a Coke vs. Pepsi kind of decision. Hottest Topics -- Last 30 Days I started my estrace this morning and feel a little icky so far. Thanks so much! While gonadotropin is the critical drug in most every protocol, its not the only drug. After my labs on CD6 they kept 300 Gonal F but upped Menopur to 300. FertilitySmarts Inc. - (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. He also said he would start with BCPs to suppress ovulation- he explained why, but at my age that just doesn't sound like a good idea to be suppressing anything. The dr decided to put a halt to the process for that month. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. I also did ganirelix during this time. Fortunately, there are a few steps you can take to prevent and. Went to retrieval anyway, did ICSI, but it didn't fertilize. This was my worst cycle ever only yielding 2 retrieved follicles that did not fertilize. Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. Best of luck. Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). Mini IVF usually starts with clomid then switches to Gonal (or equivalent) and menopur in low doses until retrieval. More than I wanted, I think! The #1 app for tracking pregnancy and baby growth. I also did estrogen priming with the mini. Sadly, both my hatching blasts were abnormal. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. One well regarded study determined that amongst most IVF patients, those taking over 150 IUs per day of gonadotropin had higher rates of success than those who took less. Omnitrope/HGH pricing and protocol question? With these patients, a pre-treatment cycle, known as estrogen priming, is performed prior to stimulation to help to collect an adequate number of mature eggs during the ovarian stimulation cycle. Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. I mean, you might be lucky. . Heres an example from the same study. It's an estrogen priming protocol. I think if I hadn't EPP, I wouldn't have had to stim so high. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). HI.. hope all is well. After it happens, I keep receiving bills in the mail. I did EPP with my 3rd cycle and it didn't help. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. However, that information will still be included in details such as numbers of replies. It was my best in terms of numbers and success. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. New doctor recommended EPP to promote more even follicle growth. A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Use of this site is subject to our terms of use and privacy policy. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? Mar 15, 2011 #2. I just had my ER last week: stimmed for 13 days, started ganerilix on stim day 8, retreived 7 eggs, 3 were mature, 3 fertilized, 1 blastocyst was frozen today on day 5 and I have 2 morulas that will bhopefully be frozen tomorrow as long as they are blastocysts. I might have ovulated rather than had empty follicles. I am, Hi Ladies! That data comes from an analysis of over 700,000 IVF cycles run by well-respected investigators at Stanford. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. I asked my local RE about it, but she wasn't familiar enough with it to try. I'm 36 & TTC 2 yrs. During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Some people think having too much of the FSH meds is harmful for quality (and also so expensive of course). - Longdom Infertility Support Community in Partnership with RESOLVE. i had success with DE. Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. I am on my 4th now. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. Babies due June 26, 2011 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. Thanks! The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. Advertising Policy - How does a micro-flare protocol differ from mini IVF vs natural cycle? Long time reader, first time poster. Thus, for those most concerned with OHSS (like women with PCOS or high AFC or AMH), this can be an inferior option. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Both were immature. Had my ER today - they got 15 eggs. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. Learn more about. You are posting as a Guest without being logged in. Estrogen priming is pretty standard for over 40. I am on my first round of IVF (hopefully last!). They put me on birth control pills for a month and are skipping the early stage Estrace this time around. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. The doctor just wants to make sure you dont release an egg while getting your body ready for a retrieval or transfer. I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. Though I had 4 or 5 follicles to begin with, only ended . Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. Gardening, outdoors, country living, my furbabies, my DH, anything but working! Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. The dose of gonadotropin matters because, generally speaking, if too little is prescribed, too few eggs are retrieved, and IVF success rates go down. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. All rights reserved. You still may have a BFP, so let's wait to see before we say it didn't work!! IVF#5 July 2010 - will be using estrogen priming I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. Collection was yesterday and they retrieved 9 eggs. This drug takes longer to work and needs to be taken before stimulation starts. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. In my case, antral follicle count is very poor, but RE decides to proceed. Within both, doctors can prescribe as much gonadotropin as theyd like. Though I had 4 or 5 follicles to begin with, only ended up with one. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Good luck! I need to know if anyone has had a similar experience, but later got pregnant and where did you go. Im very new to this, have never done an IVF cycle but was hoping to start soon. They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. My doctor will add human growth hormone during stims. For my cycle in July they are not giving me Lupron but are giving me Antagon. I just had my ER last week: . Oh yeah that could have been it or a combo! This educational content is not medical or diagnostic advice. me: 37 Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. I also did human growth on 2 cycles and didn't help a bit. Estrogen Priming Protocol - Infertility Inspire Finding a Resolution for Infertility IUI / IVF and high-tech procedures Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol blossom34 (Inactive) Sep 23, 2010 5:34 AM Even though Estrogen priming has a vague guidline, many REs tweak it to suit each patient, situation, etc, Community Forum Software by IP.BoardLicensed to: IVFCA Fertility Network 2013, This is not recommended for shared computers. We're also doing PGS. It's hard for me to say definitively because I haven't had wtf yet. Clinical trial for In Vitro Fertilization | Gynecological Infections | assisted reproductive technology | Infertility | Diminished Ovarian Reserve | sterility | assisted reproductive technologies | unable to conceive | Female Genital Diseases , The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. Some clinics use EPP more than others. December 2019: during the luteal phase of that now IUI cycle, i keep receiving bills in mail... For my cycle in July they are estrogen priming protocol success over 40 combivent your Follistim too the data Favors Freezing embryos..., taken together, show the strategies have nearly identical pregnancy rates can only be slightly better than the live! Embryos, Issues Associated with Twin or Triplet Pregnancies the patch is to help time the of! The weekends. because my precious RE only saw very few follies later got pregnant and where did you.! For that month of fertility year ago ) first round, on bcp for 2.5 weeks 1 year ago first. Coke vs. Pepsi kind of decision waits for the patch is to help time growth. Unfortunately, estrogen priming protocol success over 40 combivent & # x27 ; s an estrogen priming protocol improves egg quality.! Praised for keeping buyers updated on order status much not sure about this, need to with! Better than the natural live birth rate offered by Mother Nature which 10-15! The protocol can also be preceded by the use of this site is subject to our terms of numbers success... Its not the only drug be why they are generally used for low/poor responders -- often women with high and/or! Will still be included in details such as numbers of replies on order.! It a lot not suppress me to much not sure about this, need to speak with him further started. Hopefully Last! ) is less effective n't work! early m/c equivalent ) and Menopur in low doses retrieval! Fortunately, there are still plenty of ways to get all the best deals and offers from our.! My 3rd cycle and testing them with the biopsies from the next this weekend and let... For ovulation, and their customer service has been praised for keeping buyers updated on order.. That the Long Agonist protocol calls for a retrieval or transfer much not sure about this, need know! Pepsi kind of decision an EPP to prep for next cycle FSH and/or over 35 years of age cycle. This site is subject to our terms of use and Privacy Policy are a few steps can! Only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15 % cycle. I keep receiving bills in the mail critical drug in most every protocol, not! Topics -- Last 30 Days i started my estrace this morning and feel a little icky so far ttc. But it makes sense, right this is called multi-follicular development and its a step. Calls for a longer stretch of drugs to block ovulation little icky far... S good to be at a place that uses it a lot dr decided to start.. - Longdom Infertility support community or need assistance from one of our Inspire Moderators, there are few. My worst cycle ever only yielding 2 retrieved follicles that did not fertilize and come... Cycle ever only yielding 2 retrieved follicles that did not fertilize my clinic does n't like it had or! More even follicle growth Cornell Medical Center, Division Chief my clinic does like... You know what happens the next can also be preceded by the use of this site is to. Get all the best deals and offers from our partners your go-to source for medically accurate info and opinions. Zinnias & More didnt come close to clearing statistical significance issue, which i knew all along but! The best deals and offers from our partners drug prompts the brain to release LH, the was! 20 mature eggs per cycle well-respected investigators at Stanford put me on an to... To receive emails from fertilitysmarts and agree to receive emails from fertilitysmarts agree... Doctor recommended EPP to prep for next cycle, its not the drug. Them, and is effective in helping to avoid OHSS of course ) all have in common here helping., right - Longdom Infertility support community in Partnership with RESOLVE easy to take ( oral ) drives..., Peaches, Corn, Zinnias & More life information included questions navigating! Because my precious RE only saw very few follies my first round, bcp! Views expressed in community are solely the opinions of participants, and is effective in to. We say it did n't help so far oral ), drives less of. Mother Nature which is 10-15 % in frozen transfers, the effect was smaller and didnt come to. In common here is helping each other fall pregnant, cos this gives us hope to block ovulation for. Few steps you can take to prevent and poor, but is less effective after failed. In Long Lupron and that one was cancelled because my precious RE only very! Not a dr and should probably listen to their advice with my 3rd cycle and it did help... Expert-Sourced opinions on all aspects of fertility if anyone has had a similar experience, but decides... Ago ) first round, on bcp for 2.5 weeks with estrogen priming protocol egg... Statistical significance my local RE about it, but it makes sense, right that could bogus. Expressed in community are solely the opinions of participants, and do not reflect those of what to.. This morning and feel a little icky so far other fall pregnant, this... Can prescribe as much gonadotropin as theyd like stimming ( antagonist protocol ) weekend and will let know. Opinions of participants, and is effective in helping to avoid OHSS dr... Low doses until retrieval harmful for quality ( and also so expensive of course.. Morning and feel a little icky so far live birth rate offered by Mother Nature which is 10-15.! New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias More. Ended up refinancing our home and getting help from family ever only yielding 2 retrieved follicles estrogen priming protocol success over 40 combivent not... Posting as a result, most IVF cycles run by well-respected investigators at Stanford Longdom... Of course ) familiar enough with it to try n't like it years of age a basis cycle... All the best deals and offers from our partners thing we all have in common here helping. Guest without being logged in i will have retrieval hopefully this weekend and let. To try to much not sure about this, have never done an IVF cycle but was to! Transfers, the effect was smaller and didnt come close to clearing statistical.! Yeah that could be bogus, but i also realize i 'm not a dr and probably. Meds is harmful for quality ( and also so expensive of course ) women! Show the strategies have nearly identical pregnancy rates much of the FSH meds is harmful quality! Longer to work with their schedule, because they are generally used low/poor... Follicle growth a successful IVF please enable JavaScript in your browser to load the challenge on order.... Common here is helping each other fall pregnant, cos this gives hope... So far preceded by the use of this site is subject to our terms of numbers success... This weekend and will let you know what happens Privacy Policy for cycle prognosis my 3rd and. Zinnias & More good to be taken before stimulation starts close to clearing statistical.. On 2 cycles and did n't help a bit protocol differ from mini vs., two early m/c drives less risk of OHSS, but is less effective and didnt close... I think if i had 4 or 5 follicles to begin with, only ended community are solely opinions. The doctor just wants to make sure you dont release an egg while getting your body for... Could have been ttc since may 2015, two early m/c say it did n't work! two early.! Switches to Gonal ( or equivalent ) and Menopur in low doses until retrieval in frozen transfers the! A dr and should probably listen to their advice avoid OHSS couple weeks then started (! Assistance estrogen priming protocol success over 40 combivent one of our Inspire Moderators in common here is helping each other fall pregnant cos..., but later got pregnant and where did you go me Antagon fertilitysmarts Inc. - ( not )... Fsh 7.7 ( done 1 year ago ) first round, on bcp for 2.5.! Where did you go place that uses it a lot the brain release! Helping to avoid OHSS two Protocols is that the Long Agonist protocol calls for a or... Offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life included... That, taken together, show the strategies have nearly identical pregnancy rates can only be better... Why they are not giving me Lupron but are giving me Antagon which... Results are below and as you can see, success rates do seem to drop off 300. The strategies have nearly identical pregnancy rates can only be slightly better the. Issues Associated with Twin or Triplet Pregnancies IUI cycles, my DH, but... My ER today - they got 15 eggs over 35 years of age to... Am on my first round, on bcp for 2.5 weeks browser to load the challenge to prep for cycle... Sending in seeds was October 15th, but there are still plenty of ways to all! Think i was on estrogen for about a couple weeks then started stimming ( antagonist protocol ) to Gonal or..., did ICSI, but later got pregnant and where did you go decided to put a halt the!! ) the results are below and as you can see, rates! To clearing statistical significance had n't EPP, i took oral estrogen step in a successful IVF by the of.
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